The Delray Beach, Fla.-based retailer began talking to agencies months ago, narrowing the field from about 10 shops down to Y&R, ad industry executives said. A Y&R spokeswoman referred calls to Office Depot, which confirmed the decision.
Omnicom Group's Prometheus, meanwhile, handles media planning for the marketer.
Office Depot spent a total of $78 million on U.S. measured media in 2007, and $14 million in the first quarter of 2008, according to TNS Media Intelligence, but the marketer is expected to ramp up spending to between $100 million and $150 million, executives said.
The marketer previously worked with Omnicom Group's BBDO Worldwide and Publicis Groupe's Kaplan Thaler Group.
Office Depot markets its products via more than 1,500 worldwide retail stores, a sales force, catalogs and a massive e-commerce operation. Its annual sales are more than $15 billion.