Mr. Hopple, 49, was named chairman-CEO of a new joint venture he helped engineer with online programmer BBN.
Mr. Selkowitz, 52, takes the helm after a two-year string of big account losses in the U.S. for DMB&B. Those losses led to staff reductions in St. Louis and New York and the closing of its Chicago office.
Ross Sutherland, chief creative officer in the New York office, was assigned to a new global special projects position. No replacement was named.
In addition to heading Asia/Pacific, Mr. Selkowitz has served as worldwide account director for the agency's largest client, Procter & Gamble Co. He will be succeeded at Asia/Pacific by Roger Winter, 51, previously managing director-Asia, and on P&G by Tim Love, 46, group director on P&G for Europe, the Middle East and Africa.