A replacement was not immediately identified.
Help with transition
Ms. Cantor, who's been with the agency for 11 years, will stay on until the end of February to help with the transition.
Ms. Cantor, 38, is moving to Thinktopia, an ideas-engineering company run by a former colleague Patrick Hanlon.
Parent company Interpublic is known to be considering ways to fix Lowe, one of its biggest troublespots because of years of client losses and management turmoil.
She said the move is unrelated to a Lowe reorganization. "It has nothing to do with that and I'm not privy to those discussions."
Ammirati & Puris
Ms. Cantor joined Ammirati & Puris, now part of Lowe, in 1995 and in 2000 became the youngest female exec VP in the agency’s history. She ascended to director-client services in 2002, to president in 2004, and to CEO in 2005. She worked on a number of brands, including General Motors Corp.’s GMC and Saab.
“We appreciate all that Susan has done for the agency and wish here the best in her future endeavors,” said Mark Wnek, chairman-chief creative officer of Lowe New York.