The Super Bowl isn't only about selling: Frequently enough, its expensive ad time goes to a crusade against something or another. Most often that "something" has been cigarettes, and "another" was drugs.
The results have sometimes been powerful. In the fight against smoking, for example, American Legacy Foundation's Truth campaign and Arnold Worldwide delivered the guerilla-video "Ratman" to the 2002 game:
An earlier American Legacy Foundation shocker, "Electrolarynx," resembles more closely the harsh tone of anti-drug ads from the Office of National Drug Control Policy. Those included "I Helped," 30 seconds of unsparing linkage between "harmless" partying and drug violence:
But don't forget "Text Talk," Super Bowl 50's powerful ad advocating against a different ill (admittedly, and thankfully, not a product).