ABC's head of ad sales Geri Wang will depart from the company in March.
Ms. Wang, who had been leading ad sales at the network since 2010, will be retiring from the ad business, according to an ABC spokeswoman.
"It has been an honor and a privilege to represent ABC for these past 27 years. I truly love ABC: the people, the programs, the ideals. It's been a magnificent journey, and I want to thank my team for all of their hard work, their brilliance and their friendship. No one is luckier than me," Ms. Wong said in a statement.
A replacement for Ms. Wang has not yet been named.
Ms. Wang started as a daytime planner in 1990 and advanced through the ranks. She became senior VP of primetime sales in 2000 before ascending to president of ABC Sales in February 2010.
Her departure comes as several other familiar ad chiefs have left their posts in recent months. Joe Abruzzese will retire from Discovery Communications at the end of the year, Seth Winter stepped down from his post leading sports sales for NBC, while Arlene Manos is also retiring from AMC Networks. Jeff Lucas left Viacom this summer for a similar position at Snapchat and Fox Networks Group unexpectedly announced in September that Toby Byrne would depart from the company.