Graydon Sheppard hasn't lived in one place for more than three weeks since starting the "Shit Girls Say" web series last December. Mr. Sheppard and co-creator Kyle Humphrey were astonished by the traffic the videos drew--2 million views in one day. It all started when one of them asked, "Could you pass me that blanket?" in that, like, girlish twang. Out of fun, they started "a word document and within a few days, had a hundred," said Mr. Sheppard. They ran with it and started a Twitter account--which now has nearly 1.5 million fans. Then followed the videos, with Mr. Sheppard playing the role of "Girl."

A filmmaker and avid storyteller, Mr. Sheppard is represented by The Director's Bureau and preparing a picture book based on the Twitter feed with Harlequin publishers.

See the rest of the 2012 Creativity 50 here.